Cellular / Tissue

Biorepository & Tissue Analysis Shared Resource


Chadrick E. Denlinger, MD
E-mail: denlinge@musc.edu


Richard R. Drake, PhD
E-mail: draker@musc.edu

Operations Manager:

Kiki Gibbs
Phone: 843-876-2345
Fax: 843-876-2346
E-mail: gibbski@musc.edu

Location: BEB 421



The Hollings Cancer Center (HCC) Biorepository & Tissue Analysis (BTA) Shared Resource provides investigators with access to meticulously collected and annotated human specimens as well as advanced human and animal tissue analyses that require state-of-the-art instrumentation and expertise. The shared resource comprises several integrated components, e.g., biospecimen and data repository, customized and readily available tissue microarrays (TMAs), laser capture microdissection (LCM), matrix-assisted laser desorption/ionization (MALDI) tissue imaging, and research pathology services such as histologic analysis of fixed, frozen, and stained tissues and analysis of experimental results.

The specific objectives of the HCC BTA Shared Resource are to:

  • Populate a central biospecimen and data repository.
    • Collect, process, and store human tissues according to established standard operating procedures (SOPs) with quality control verified by experienced pathologists at the time of accession. 
    • Collect, process, and store saliva, urine, plasma, buffy coat, and other protocol-specific human biospecimens at the time of surgery/procedure according to established SOPs. 
    • Link clinicopathologic data for each human specimen for research use.
    • Provide custom human TMAs in a cost-effective manner.
  • Provide, develop, and modify tissue analysis services to support cancer research (human and animal), including:
    • Routine and custom staining procedures.
    •  Laser capture microscopy. 
    •  DNA/RNA/protein isolation.
    •  MALDI tissue imaging and advanced molecular analysis by mass spectrometry.
  • Collaborate with other MUSC/HCC entities and shared resources to enhance the capabilities and cost-effectiveness of the BTA.


HCC members, SCTR Investigators & MUSC Investigators