Analytical Research

 Lipidomics

Director:

Besim Ogretmen, PhD
Professor of Biochemistry & Molecular Biology
Email: ogretmen@musc.edu

Scientific Director:

Alicja Bielawska, PhD
Research Professor of Biochemistry & Molecular Biology
Phone: 843-792-0273
E-Mail: bielawsk@musc.edu

Website:

http://hcc.musc.edu/research/resources/lipidomics/

Description:

The mission of the Lipidomics Shared Resource is to provide advanced methodology, state-of-the-art facilities, and expertise for both synthesis and analysis of bioactive lipids in a cost-effective manner for the Hollings Cancer Center. The Lipidomics Shared Resource represents a unique scientific service for the measurement of bioactive lipid molecules with a particular focus on their role in cancers. The Lipidomics Shared Resource is organized into two units – the Lipid Synthesis Unit and the Lipid Analysis Unit

The purposes of the Lipidomics Shared Resource are to:

  • Provide synthetic lipids, analogs, and inhibitors of lipid metabolism with an emphasis on sphingolipids.
  • Provide qualitative and quantitative analysis of lipid composition from biological materials with a current listing of more than 300 distinct molecular species.
  • Improve and develop new techniques for extended lipid analyses by providing a database of the lipid composition of normal and transformed cells and organelles that will permit a lipidomics approach to analysis of their cellular metabolism.
  • Develop cutting-edge synthetic molecular tools to study the role of bioactive lipids as new potential anticancer agents.
  • Develop lead compounds for translational studies. The Lipidomics Shared Resource’s library of synthetic lipids, derivatives, and related molecules currently exceeds 600 compounds, several of which are emerging as important inhibitors of enzymes of sphingolipid metabolism and being tested in clinical trials.
  • Educate and assist HCC investigators in designing and conducting experimental approaches aimed at the study of bioactive lipids, their metabolism, quantitation, and function.

Accessibility:

Services are provided for anyone in need of lipid analysis and synthetic tools to explore lipid biology, at MUSC and outside, including industry.

However, price for the service depends on the affiliation.