Analytical Research

Nuclear Magnetic Resonance Facilities

NMR Core Facility Manger & Contact:

Dr. Stuart Parnham
Phone:
843-876-2384
Email: parnham@musc.edu

Location:

MUSC - Drug Discovery Building 115

Website:    

https://academicdepartments.musc.edu/sbc/nmr_website/nmr/index.htm

Description:

Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique that can provide detailed information on the three-dimensional structure of biological molecules in solution. NMR can be used to characterize the notional flexibility in atomic level detail which can lead to a more complete understanding macromolecular function. Molecular recognition processes necessitate conforational flexibility and liquid state NMR spectroscopy in uniquely suited to answer important questions in this area by looking at dynamic ensembles of structures. Recently, MUSC has acquired the capability for high field NMR spectroscopy, paving the way for investigators to determine the structures and dynamics of macromolecules by this technique.